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MOTS-C
MOTS-C - Image 2

MOTS-C

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MOTS-C

Islip

Pickup available, usually ready in 24 hours

3 Grant Ave.
Ste. B
Islip NY 11751
United States
+16316770030

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA type-C) is a 16-amino-acid peptide encoded by mitochondrial DNA. It regulates metabolism, enhances insulin sensitivity, supports fat loss, and may improve longevity. As a mitochondrial-derived signaling peptide, MOTS-C activates AMPK and other key energy-related pathways, positioning it as a promising candidate for anti-aging, metabolic disorders, and performance enhancement.

Applications
  • Type 2 diabetes and insulin resistance
  • Fat loss and metabolic optimization
  • Longevity and cellular anti-aging support
  • Endurance and muscle recovery
  • Neuroprotection and cognitive function
  • Cardiovascular protection
  • Mitochondrial dysfunction and metabolic syndrome
Mechanism of Action

AMPK Activation: MOTS-C stimulates AMPK, enhancing glucose uptake, fatty acid oxidation, and mitochondrial ATP production
Exercise-Mimetic Effect: Mimics physical activity at the cellular level, boosting metabolic health and endurance
FOXO3 Activation: Upregulates longevity-related genes, protecting against stress and cellular aging
Mitochondrial Signaling: Regulates mitochondrial and nuclear gene expression to optimize cellular energy status
Neuro- and Cardioprotection: Reduces oxidative stress and inflammation in neural and cardiovascular tissues

Key Research Studies

1. Metabolic Regulation & Insulin Sensitivity

  • Study focus: Effects on glucose metabolism and insulin response
  • Key findings: Activated AMPK, improved insulin sensitivity, and prevented diet-induced obesity in mice
  • Reference: Cell Metabolism, 2015

2. Longevity & Anti-Aging Effects

  • Study focus: Aging and mitochondrial health
  • Key findings: Activated FOXO3, preserved mitochondrial function, and extended lifespan in mice
  • Reference: Nature Communications, 2019

3. Exercise Performance & Muscle Recovery

  • Study focus: Mitochondrial efficiency and endurance
  • Key findings: Improved exercise capacity, reduced fatigue, and enhanced muscle adaptation
  • Reference: Science Advances, 2021

4. Cardiovascular Protection

  • Study focus: Heart health and vascular inflammation
  • Key findings: Reduced oxidative stress and inflammation, protected against heart disease
  • Reference: Circulation Research, 2020

5. Neuroprotection & Cognitive Function

  • Study focus: Brain cell resilience and neurodegeneration
  • Key findings: Preserved neuronal mitochondrial function, reduced cognitive decline risk
  • Reference: Journal of Neuroscience Research, 2022

Biological Effects and Benefits

Insulin Sensitivity & Glucose Control:

Improves metabolic efficiency and helps manage Type 2 diabetes

Fat Loss & Energy Regulation:

Promotes AMPK activation for increased fat oxidation and ATP production

Endurance & Recovery:

Enhances mitochondrial capacity and post-exercise muscle regeneration

Biological Effects Image

Anti-Aging & Longevity:

Supports mitochondrial health and upregulates longevity genes like FOXO3

Neuroprotective Effects:

Shields neurons from oxidative damage, potentially preventing cognitive decline

Cardiovascular Health:

Reduces inflammation, supports vascular function, and protects against heart disease

Molecular Structure

Molecular Structure
  • Sequence: EQKIKLLLPRGTTRS
  • Molecular Formula: C87H133N23O26
  • Molecular Weight: ~1620.2 g/mol
  • Structure Notes: 16-amino acid mitochondrial peptide; influences nuclear gene expression and mitochondrial function through signaling cascades such as AMPK activation

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