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GLP-1

GLP-1

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SKU: sema-glp-1 Categories: , , ,

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GLP-1

Islip

Pickup available, usually ready in 24 hours

3 Grant Ave.
Ste. B
Islip NY 11751
United States
+16316770030

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist used for the management of type 2 diabetes and chronic weight control. It mimics the body’s natural GLP-1 hormone to improve blood sugar control, reduce appetite, and support weight loss. Semaglutide is available in both injectable and oral forms and is also the active ingredient in branded medications like Wegovy and Ozempic.

Applications
  • Type 2 diabetes management
  • Chronic weight loss and obesity treatment
  • Appetite suppression
  • Cardiovascular risk reduction
  • Potential reduction in Alzheimer’s disease risk (under investigation)
Mechanism of Action

GLP-1 Receptor Activation: Mimics native GLP-1 to increase insulin and decrease glucagon based on blood glucose levels
Brain-Targeted Appetite Control: Acts on the hypothalamus to decrease hunger and promote satiety
Gastrointestinal Modulation: Slows gastric emptying for better glucose control and appetite regulation
Systemic Metabolic Effects: Supports weight loss, glucose homeostasis, and cardiovascular improvements

Key Research Studies

1. Long-Term Weight Loss

  • Study focus: Obesity treatment with 10 mg dose
  • Key findings: Over 68 weeks, 50% of participants lost ≥15% of body weight, 33% lost ≥20%
  • Reference: Welcome to UCLA Health

2. Comparison with Tirzepatide

  • Study focus: Comparative weight loss efficacy
  • Key findings: Both effective, with tirzepatide offering slightly more weight loss; semaglutide showed fewer nausea incidents (14%)
  • Reference: JAMA Network, PMC

3. Cardiovascular and Longevity Effects

  • Study focus: Mortality and heart health in diabetic patients
  • Key findings: Reduces cardiovascular risk, possibly lowers all-cause mortality including from infections
  • Reference: The Guardian

4. Neuroprotection & Alzheimer’s Risk

  • Study focus: Risk of Alzheimer’s in older diabetic patients
  • Key findings: Early data suggests a lower incidence of Alzheimer’s with semaglutide use
  • Reference: People.com

Biological Effects and Benefits

Improved Insulin Secretion:

Stimulates pancreatic beta cells to release insulin when blood glucose is high

Reduced Glucagon Secretion:

Limits hepatic glucose production, lowering fasting glucose

Slowed Gastric Emptying:

Prolongs fullness and moderates post-meal blood sugar spikes

Appetite Suppression:

Acts on the hypothalamus to reduce hunger and food intake

Biological Effects Image

Weight Loss:

Promotes consistent and substantial fat reduction

Cardiovascular Benefits:

Lowers blood pressure, improves lipid profile, and reduces cardiovascular events in diabetics

Possible Longevity & Neuroprotection:

Emerging links to reduced mortality and Alzheimer’s risk

Molecular Structure

Molecular Structure
  • Peptide Sequence: H-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Glu-γ-Glu-C18 fatty acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
  • Molecular Formula: C187H291N45O59
  • Molecular Weight: 4113.58 g/mol
  • CAS Number: 910463-68-2
  • Structure Notes: Modified GLP-1 analogue with fatty acid chain for prolonged activity and weekly dosing

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