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Ultra Pure Peptides - Research Use Only - Raw Material Sourced from the USA

IGF-1 LR3

IGF-1 LR3

$110.00

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IGF-1 LR3

Islip

Pickup available, usually ready in 24 hours

3 Grant Ave.
Ste. B
Islip NY 11751
United States
+16316770030

IGF-1 LR3 is a synthetic, long-acting analog of insulin-like growth factor 1 (IGF-1), a naturally occurring growth factor involved in muscle repair, fat metabolism, cell regeneration, and anabolic growth. The LR3 version has been chemically modified for increased potency and a significantly extended half-life. It is commonly used for muscle development, anti-aging, and recovery.

Applications
  • Muscle hypertrophy and strength enhancement
  • Injury recovery and soft tissue repair
  • Fat loss with lean mass preservation
  • Anti-aging and cellular regeneration
  • Cognitive function and neuroprotection
  • Bone density and osteoblast support
  • Metabolic regulation and improved insulin sensitivity
Mechanism of Action

IGF-1 Receptor Binding: Binds to IGF1R on muscle, bone, nerve, and skin cells, activating anabolic signaling cascades
PI3K-Akt Pathway Activation: Stimulates protein synthesis, cell survival, and muscle growth
MAPK/ERK Pathway Activation: Promotes cell proliferation, repair, and differentiation
Reduced IGFBP Binding: Modified to avoid IGF binding proteins, allowing for more bioactive IGF-1 availability
Insulin-Like Effects: Enhances glucose uptake and nutrient partitioning toward muscle over fat

Key Research Studies

1. IGF-1 and Muscle Growth

2. IGF-1 in Aging and Sarcopenia

3. IGF-1 and Neuroprotection

4. IGF-1 and Bone Density

5. IGF-1 and Insulin Sensitivity

6. IGF-1 LR3 Enhanced Potency

  • Findings: Extended half-life and reduced IGFBP binding increase anabolic effects
  • Summary Article: “IGF-1 and its analogs: potential for treating muscle wasting”
  • PMID: https://pubmed.ncbi.nlm.nih.gov/15959526/

Biological Effects and Benefits

Muscle Growth:

Stimulates hypertrophy and hyperplasia

Fat Loss:

Boosts metabolic rate and preserves lean tissue

Recovery:

Accelerates soft tissue healing and repair

Anti-Aging:

Promotes collagen synthesis and cellular longevity

Biological Effects Image

Neuroprotection:

Enhances brain function and protects neurons

Bone Health:

Improves bone density and regeneration

Glucose Uptake:

Increases nutrient partitioning and mimics insulin

Molecular Structure

Molecular Structure
  • Peptide Type: Recombinant polypeptide
  • Sequence Length: 83 amino acids (natural IGF-1 has 70)
  • Molecular Weight: ~9.2 kDa
  • Modifications:
  • Arginine substituted at position 3 (“R3”)
  • Addition of 13 extra amino acids to prolong half-life
  • Half-life: ~20–30 hours (vs. ~30 minutes for native IGF-1)

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