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Retatrutide (GLP-3)

Retatrutide (GLP-3)

$299.00

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Retatrutide (GLP-3)

Islip

Pickup available, usually ready in 24 hours

3 Grant Ave.
Ste. B
Islip NY 11751
United States
+16316770030

Retatrutide is an investigational triple hormone receptor agonist developed by Eli Lilly for treating obesity, type 2 diabetes, and metabolic disorders. It activates GLP-1, GIP, and glucagon receptors to induce weight loss, improve insulin sensitivity, enhance energy expenditure, and regulate appetite. With Phase 2 trials showing significant results, Retatrutide is considered a next-generation metabolic therapy with broad therapeutic potential.

Applications
  • Obesity and weight loss
  • Type 2 diabetes and glycemic control
  • Metabolic syndrome and insulin resistance
  • Fatty liver disease (NAFLD)
  • Cardiovascular risk reduction
  • Appetite suppression and energy balance
Mechanism of Action

GLP-1 Receptor Agonism: Enhances insulin secretion post-meal, suppresses glucagon, delays gastric emptying, and reduces appetite
GIP Receptor Agonism: Boosts insulin secretion and sensitivity, may support lipid metabolism and fat oxidation
Glucagon Receptor Agonism: Increases energy expenditure, promotes lipolysis, and may aid in preserving lean muscle mass

Key Research Studies

1. Substantial Weight Reduction

2. Glycemic Control in Type 2 Diabetes

  • Study focus: Blood sugar regulation in diabetic patients
  • Key findings: Significant HbA1c reduction and insulin sensitivity improvement
  • Reference: The Lancet

3. Liver Fat Reduction

  • Study focus: NAFLD and liver health
  • Key findings: Up to 82% reduction in liver fat content
  • Reference: Nature

4. Cardiovascular Biomarkers

  • Study focus: Lipid profile and heart health
  • Key findings: 40.6% reduction in triglycerides and 38% reduction in apoC-III
  • Reference: Reuters

Biological Effects and Benefits

Unprecedented Weight Loss:

Up to 24.2% body weight loss; more effective than other anti-obesity drugs

Diabetes Management:

Lowers blood glucose, HbA1c, and improves insulin sensitivity

Fat Loss & Energy Expenditure:

Activates glucagon receptor to boost calorie burning and fat breakdow

Liver Health:

Reduces liver fat, supports NAFLD management

Biological Effects Image

Cardiovascular Health:

Lowers triglycerides, cholesterol, and blood pressure

Appetite Suppression:

Delays gastric emptying and increases satiety

Muscle Preservation (Potential):

May preserve lean mass during fat loss through glucagon signaling

Molecular Structure

Molecular Structure
  • Peptide Sequence:

Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂ (Sodium salt)

  • Molecular Formula: C78H121N21O23S2
  • Molecular Weight: 4731.33 g/mol
  • Notes: Synthetic peptide drug engineered for triple receptor activity with metabolic and weight regulation benefits

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