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Ultra Pure Peptides - Research Use Only - Raw Material Sourced from the USA

SS-31

SS-31

$155.00

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SS-31

Islip

Pickup available, usually ready in 24 hours

3 Grant Ave.
Ste. B
Islip NY 11751
United States
+16316770030

SS-31 is a mitochondria-targeted synthetic peptide from the Szeto-Schiller (SS) family, designed to protect and restore mitochondrial function. It selectively accumulates in the inner mitochondrial membrane (IMM), stabilizes cardiolipin, reduces oxidative stress, and enhances ATP production. SS-31 has been widely studied for its therapeutic potential in neurodegenerative, cardiovascular, metabolic, and renal conditions where mitochondrial dysfunction is a core issue.

Applications
  • Neurodegenerative diseases (Alzheimer’s, Parkinson’s, ALS)
  • Heart failure and cardiac ischemia
  • Mitochondrial myopathy and aging-related muscle decline
  • Chronic kidney disease and acute kidney injury
  • Inflammation and oxidative stress-related disorders
  • Metabolic health and insulin sensitivity
Mechanism of Action

Mitochondrial Targeting via Cardiolipin Binding: Rapid cellular uptake and localization to the inner mitochondrial membrane by binding to cardiolipin
Cristae and IMM Stabilization: Preserves mitochondrial structure, preventing apoptosis and membrane degradation
ROS Reduction: Limits electron leakage and reduces mitochondrial-generated oxidative stress
ATP Production Optimization: Enhances electron transport chain performance, boosting energy output

Key Research Studies

1. Mitochondrial Protection & ATP Restoration

  • Study focus: Cardiolipin binding and ATP production
  • Findings: Stabilized IMM structure, improved ETC function, enhanced ATP production
  • Reference: Szeto HH et al., 2011

2. Reduction of Oxidative Stress & Inflammation

  • Study focus: ROS and cytokine levels in cardiac injury
  • Findings: Decreased oxidative stress and inflammatory markers
  • Reference: Birk AV et al., 2013

3. Neurodegenerative Disease Models

  • Study focus: Cognitive function in Alzheimer's models
  • Findings: Reduced neuroinflammation, improved mitochondrial health and memory
  • Reference: Yang L et al., 2020

4. Cardioprotection in Heart Failure

  • Study focus: Heart failure with reduced ejection fraction (HFrEF)
  • Findings: Preserved cardiac output and mitochondrial respiration
  • Reference: MMPOWER-3 Phase 2 Clinical Trial

5. Muscle Function & Metabolism

  • Study focus: Muscle fatigue and mitochondrial performance
  • Findings: Improved endurance, mitochondrial output, and insulin sensitivity
  • Reference: Campbell MD et al., 2019

6. Kidney Protection

  • Study focus: Ischemia and oxidative injury in kidneys
  • Findings: Reduced kidney damage, preserved mitochondrial integrity
  • Reference: Szeto HH et al., 2017

Biological Effects and Benefits

Mitochondrial Protection:

Preserves IMM structure, reduces dysfunction

Oxidative Stress Reduction:

Lowers ROS, limits lipid/protein/DNA damage

Enhanced ATP Production:

Boosts ETC efficiency and mitochondrial respiration

Anti-Inflammatory:

Reduces pro-inflammatory cytokines linked to chronic disease

Biological Effects Image

Neuroprotection:

Protects neurons, improves cognitive and motor function

Cardioprotection:

Minimizes ischemia-reperfusion injury, improves cardiac output

Muscle Recovery & Endurance:

Improves muscle strength, reduces fatigue

Renal Health:

Reduces ischemic and oxidative kidney damage

Molecular Structure

Molecular Structure
  • Sequence: D-Arg-2′,6′-dimethyltyrosine-Lys-Phe-NH₂
  • Molecular Formula: C₃₀H₅₀N₈O₇
  • Molecular Weight: 639.77 g/mol
  • Structure Notes: Cell-permeable tetrapeptide with high affinity for cardiolipin; accumulates in mitochondria without the need for a targeting sequence

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