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Ultra Pure Peptides - Research Use Only - Raw Material Sourced from the USA

Thymosin Alpha-1

Thymosin Alpha-1

$128.00

SKU: thymalpha-1 Categories: , ,

Pickup available at Islip

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Thymosin Alpha-1

Islip

Pickup available, usually ready in 24 hours

3 Grant Ave.
Ste. B
Islip NY 11751
United States
+16316770030

Thymosin Alpha-1 is a naturally occurring peptide composed of 28 amino acids, originally derived from prothymosin alpha in the thymus gland. It plays a key role in immune regulation, particularly in T-cell maturation and immune response coordination. Tα1 is used therapeutically to enhance immune function in immunocompromised individuals, support vaccine efficacy, and assist in the treatment of viral, bacterial, and autoimmune conditions.

Applications
  • Immune system modulation and support
  • Antiviral therapy (e.g., HBV, HCV, HIV, influenza, COVID-19)
  • Autoimmune disease regulation (e.g., RA, lupus, MS, IBD)
  • Sepsis and bacterial/fungal infection support
  • Immune restoration in elderly or immunocompromised individuals (e.g., post-chemotherapy, transplant patients, HIV/AIDS)
  • Vaccine response enhancement
Mechanism of Action

T-cell Activation: Stimulates maturation and differentiation of helper (CD4⁺) and cytotoxic (CD8⁺) T-cells, enhancing adaptive immunity
Dendritic and Macrophage Activation: Improves antigen presentation, boosting pathogen detection and immune response
Cytokine Regulation: Increases production of key cytokines (e.g., IFN-α, IL-2) for antiviral and immune-promoting effects
Anti-inflammatory Activity: Helps maintain immune homeostasis by reducing excessive cytokine release and preventing cytokine storms

Key Research Studies

1. Immune Enhancement & Modulation

  • Focus: General immune stimulation in immunodeficient patients
  • Findings: Enhances T-cell activity, dendritic function, and vaccine responses
  • Reference: PubMed+1WJGNet+1

2. Sepsis Treatment

  • Focus: Efficacy in reducing mortality in septic patients
  • Findings: Mixed results; some benefit in older patients or those with chronic conditions, others show no significant mortality improvement
  • Reference: Exploration Publishing+2BMJ+2BioMed Central+2

Biological Effects and Benefits

Immune System Enhancement:

Activates CD4+ and CD8+ T-cells, enhances NK cell function, and stimulates dendritic cells and macrophages

Antiviral Protection:

Increases interferon-α and immune recognition against HBV, HCV, HIV, and respiratory viruses

Antibacterial and Antifungal Activity:

Boosts phagocytic activity and immune defense in septic or immunocompromised hosts

Biological Effects Image

Autoimmune Modulation:

Balances Th1/Th2 responses and regulates cytokine production to prevent excessive inflammation

Vaccine Enhancement:

Improves vaccine efficacy in older adults or immunosuppressed individuals

Immune Restoration:

Aids immune recovery post-chemotherapy, in elderly patients, and in chronic immunodeficiency conditions

Molecular Structure

Molecular Structure
  • Peptide Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
  • Molecular Formula: C129H215N33O55
  • Molecular Weight: ~3,108 Da
  • Structure Notes: Linear peptide with strong immunomodulatory properties, acetylated at the N-terminus

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